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San Crisogono is a church in Rome (rione Trastevere) dedicated to the martyr Saint Chrysogonus. It was one of the tituli, the first parish churches of Rome, and was probably built in the 4th century under Pope Sylvester I (314–335).
The area beneath the sacristy was investigated by Fr. L. Manfredini and Fr. C. Piccolini in 1907. They found remains of the first church. The area was then excavated and studied.
The church is served by Trinitarians. Among the previous Cardinal Priests was Vincenzo Gioacchino Raffaele Luigi Pecci (1853–1878), elected Pope Leo XIII. San Crisogono is the station church for Monday, the fifth week of Lent.